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Article

The BXH2 mutation in IRF8 differentially impairs dendritic cell subset development in the mouse.

Blood - 15 Feb 2008

Tailor Prafullakumar, Tamura Tomohiko, Morse Herbert C, Ozato Keiko

Abstract excerpt

Among dendritic cell (DC) subsets, CD8alpha(+) DCs and plasmacytoid DCs (pDCs) produce high levels of IL12 and type I interferons (IFNs), respectively, and confer early innate immunity. Development of CD8alpha(+) DCs and pDCs requires the interferon regulatory factor 8 (IRF8). Recently, a spontaneous point mutation was identified in the Irf8/Icsbp gene in the BXH2 mouse, which exhibits an immunodeficient...

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Identifiers

PMID: 18055870
DOI: 10.1182/blood-2007-07-100750
PMCID: PMC2234043

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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