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Article

Sp1 and Smad transcription factors co-operate to mediate TGF-beta-dependent activation of amyloid-beta precursor protein gene transcription.

The Biochemical journal - 15 Oct 2004

Docagne Fabian, Gabriel Cecilia, Lebeurrier Nathalie, Lesné Sylvain, Hommet Yannick, Plawinski Laurent, Mackenzie Eric T, Vivien Denis

Abstract excerpt

Abnormal deposition of Abeta (amyloid-beta peptide) is one of the hallmarks of AD (Alzheimer's disease). This peptide results from the processing and cleavage of its precursor protein, APP (amyloid-beta precursor protein). We have demonstrated previously that TGF-beta (transforming growth factor-beta), which is overexpressed in AD patients, is capable of enhancing the synthesis of APP by astrocytes by a...

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Identifiers

PMID: 15242331
DOI: 10.1042/BJ20040682
PMCID: PMC1134081

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Sp1 and Smad transcription factors co-operate to mediate TGF-beta-dependent activation of amyloid-beta precursor protein gene transcription.PMID 15242331Read ↗

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