Article
Oct-1, silencer sequence, and GC box regulate thyroid hormone receptor beta1 promoter.
Molecular and cellular endocrinology - 20 Jun 1997
Nagasawa T, Takeda T, Minemura K, DeGroot L J
Abstract excerpt
Thyroid hormone, acting through thyroid hormone receptors (TRs), plays a crucial role in brain development and its insufficiency results in irreversible brain damage. TR alpha mRNA is expressed continuously from early embryonic stages, but the level of TR beta1 mRNA in brain is more abundant in a...
Topics
- Animals
- Base Sequence
- Brain
- COS Cells
- Carrier Proteins
- Fetus
- Gene Expression Regulation, Developmental
- Membrane Proteins
- Mice
- Models, Biological
- Mutation
- Oligonucleotide Probes
- Organic Cation Transporter 1
- Promoter Regions, Genetic
- RNA, Messenger
- Receptors, Thyroid Hormone
- Transfection