Characterization of the <i>APP</i> proximal promoter and 5′‐untranslated regions: identification of cell‐type specific domains and implications in <i>APP</i> gene expression and Alzheimer's disease

Abstract excerpt

Alzheimer's disease is characterized by brain deposition of toxic amyloid beta-peptide (Abeta), generated from the Abeta precursor protein (APP). APP gene expression is regulated via the proximal promoter region (PPR; -46/-1 in the human sequence; +1 transcription start) and the 5'-untranslated region (5'-UTR; +1/+147). We have recently identified a unique CAGA sequence, "amyloid" (+83/+86) present only in the...

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