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Thyroid Hormones Regulate β-Amyloid Gene Splicing and Protein Secretion in Neuroblastoma Cells<sup>1</sup>

1 Jun 1998

Abstract excerpt

The beta-amyloid protein (Abeta), the major component of the senile plaques found in Alzheimer brains, derives from a larger beta-amyloid precursor protein (APP). Alternative splicing of the APP gene yields three major APP messenger RNAs (mRNAs), which, in turn, give rise to the APP770, APP751, and APP695 protein isoforms. In this study we examined the effects of thyroid hormone on APP expression in N2a-beta...

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PMID: 9607774
DOI: 10.1210/endo.139.6.6033

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