Article
Protons activate brain Na+ channel 1 by inducing a conformational change that exposes a residue associated with neurodegeneration.
The Journal of biological chemistry - 13 Nov 1998
Adams C M, Snyder P M, Price M P, Welsh M J
Abstract excerpt
BNC1 is a mammalian neuronal cation channel in the novel DEG/ENaC ion channel family. BNC1 channels are transiently activated by extracellular protons and are constitutively activated by insertion of large residues, such as valine, in place of Gly-430; residue 430 is a site where analogous mutati...
Topics
- Amino Acid Substitution
- Animals
- Cold Temperature
- Degenerin Sodium Channels
- Epithelial Sodium Channels
- Ethyl Methanesulfonate
- Female
- Indicators and Reagents
- Ion Channel Gating
- Ion Channels
- Mesylates