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Article

Betaine acts on a ligand-gated ion channel in the nervous system of the nematode C. elegans.

Nature neuroscience - 1 Dec 2013

Peden Aude S, Mac Patrick, Fei You-Jun, Castro Cecilia, Jiang Guoliang, Murfitt Kenneth J, Miska Eric A, Griffin Julian L, Ganapathy Vadivel, Jorgensen Erik M

Abstract excerpt

Prior to the advent of synthetic nematocides, natural products such as seaweed were used to control nematode infestations. The nematocidal agent in seaweed is betaine, an amino acid that functions as an osmolyte and methyl donor. However, the molecular mechanisms of betaine toxicity are unknown. We identified the betaine transporter SNF-3 and the betaine receptor ACR-23 in the nematode C. elegans. Mutating snf-3...

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Identifiers

PMID: 24212673
DOI: 10.1038/nn.3575
PMCID: PMC3955162

Genes

ACR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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