Paradoxical stimulation of a DEG/ENaC channel by amiloride.

Abstract excerpt

Extracellular amiloride inhibits all known DEG/ENaC ion channels, including BNC1, a proton-activated human neuronal cation channel. Earlier studies showed that protons cause a conformational change that activates BNC1 and exposes residue 430 to the extracellular solution. Here we demonstrate that, in addition to blocking BNC1, amiloride also exposes residue 430. This result suggested that, like protons, amiloride...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Acid Sensing Ion Channels
• Share to Amiloride
• Share to Epithelial Sodium Channels