Article
A common p73 polymorphism is associated with a reduced incidence of oesophageal carcinoma.
British journal of cancer - 16 Nov 2001
Ryan B M, McManus R, Daly J S, Carton E, Keeling P W, Reynolds J V, Kelleher D
Abstract excerpt
The incidence of oesophageal adenocarcinoma is rising; to date, no susceptibility genes have been identified. p73, a novel p53 homologue, maps to chromosome 1p36, a region commonly deleted in oesophageal cancers. p73 shares some p53-like activity, but in addition, may also play a role in gastrointestinal epithelial inflammatory responses. A non-coding p73 polymorphism (denoted AT or GC) may be functionally...
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