Somatic mutations in the BRCA1 gene in sporadic ovarian tumours.

doi:10.1038/ng0495-439

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Article

Somatic mutations in the BRCA1 gene in sporadic ovarian tumours.

Nature genetics - 1 Apr 1995

Merajver S D, Pham T M, Caduff R F, Chen M, Poy E L, Cooney K A, Weber B L, Collins F S, Johnston C, Frank T S

Abstract excerpt

The BRCA1 gene on chromosome 17q21 is responsible for an autosomal dominant syndrome of increased susceptibility to breast and ovarian cancer but no somatic mutations in tumours have yet been described. To study the potential role of BRCA1 in sporadic carcinogenesis, we analysed the genomic DNA o...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
Amino Acid Sequence
Base Sequence
Chromosomes, Human, Pair 17
DNA, Neoplasm
Female
Genes, Dominant
Genes, Tumor Suppressor
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Molecular Sequence Data

Mutation

Oncogenes

Ovarian Neoplasms

Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 7795652
DOI: 10.1038/ng0495-439

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7795652-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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