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Article

Prevalence of BRCA1 mutations in familial and sporadic greek ovarian cancer cases.

PloS one - 1 Jan 2013

Stavropoulou Alexandra V, Fostira Florentia, Pertesi Maroulio, Tsitlaidou Marianthi, Voutsinas Gerassimos E, Triantafyllidou Olga, Bamias Aristotelis, Dimopoulos Meletios A, Timotheadou Eleni, Pectasides Dimitrios, Christodoulou Christos, Klouvas George, Papadimitriou Christos, Makatsoris Thomas, Pentheroudakis George, Aravantinos Gerasimos, Karydakis Vassilis, Yannoukakos Drakoulis, Fountzilas George, Konstantopoulou Irene

Abstract excerpt

Germline mutations in the BRCA1 and BRCA2 genes contribute to approximately 18% of hereditary ovarian cancers conferring an estimated lifetime risk from 15% to 50%. A variable incidence of mutations has been reported for these genes in ovarian cancer cases from different populations. In Greece, six mutations in BRCA1 account for 63% of all mutations detected in both BRCA1 and BRCA2 genes. This study aimed to...

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Age Factors
Age of Onset
Family
Genes, BRCA1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ovarian Neoplasms

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Open in PubMed Open full text

Identifiers

PMID: 23536787
DOI: 10.1371/journal.pone.0058182
PMCID: PMC3594241

Genes

BRCA1
BRCA2

Variants

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