Article
Genetic stability of oral polio vaccine prepared on primary monkey kidney cells or Vero cells--effects of passage in cell culture and the human gastrointestinal tract.
Vaccine - 1 Dec 1998
Chezzi C, Dommann C J, Blackburn N K, Maselesele E, McAnerney J, Schoub B D
Abstract excerpt
The genetic stability of the three Sabin oral poliovaccine (OPV) strains produced on either primary monkey kidney (VK) or Vero cell substrates was compared in vivo and in vitro by measuring the rate at which the bases most strongly associated with attenuation and reversion to neurovirulence (posi...
Topics
- Animals
- Cells, Cultured
- Chlorocebus aethiops
- Digestive System
- Drug Stability
- Feces
- Humans
- Kidney
- Phenotype
- Poliovirus
- Poliovirus Vaccine, Oral
- Vaccines, Attenuated
- Vero Cells
- Viral Load