Impaired spatial navigation learning in transgenic mice over-expressing heme oxygenase-1.

doi:10.1016/s0006-8993(98)00803-8

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Article

Impaired spatial navigation learning in transgenic mice over-expressing heme oxygenase-1.

Brain research - 12 Oct 1998

Morgan D, Holcomb L, Saad I, Gordon M, Mahin Maines

Abstract excerpt

Transgenic mice expressing heme oxygenase-1 (HO-1) using the neuron-specific enolase promoter were impaired in learning the Morris water maze compared to nontransgenic littermates. The memory of the HO-1 mice for the location of the platform was similarly impaired when tested using a probe trial...

Topics

Animals
Escape Reaction
Genotype
Heme Oxygenase (Decyclizing)
Heme Oxygenase-1
Maze Learning
Membrane Proteins
Memory
Mice
Mice, Transgenic
Psychomotor Performance
Reaction Time
Space Perception

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