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Article

Spatial learning deficit in dopamine D(1) receptor knockout mice.

European journal of pharmacology - 27 Oct 1999

El-Ghundi M, Fletcher P J, Drago J, Sibley D R, O'Dowd B F, George S R

Abstract excerpt

Dopamine D(1) receptors are expressed in the hippocampus and prefrontal cortex, suggesting a role in cognition. Dopamine D(1) receptor-deficient mice (D(1)-/-) were used to investigate the role of this receptor in spatial learning and memory. Using the Morris water maze, mice were trained to locate a hidden platform. Subsequently, the platform was removed from the maze and mice were scored for the percentage of...

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Source

Identifiers

PMID: 10585522
DOI: 10.1016/s0014-2999(99)00573-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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