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Article

The spatial learning phenotype of heterozygous leaner mice is robust to systematic variation of the housing environment.

Comparative medicine - 1 Apr 2009

Marques Joana M, Alonso Isabel, Santos Cristina, Silveira Isabel, Olsson I Anna S

Abstract excerpt

Providing stimulation and allowing the performance of motivated behaviors through environmental enrichment improves learning and memory in rodents and delays cognitive impairment in neurodegenerative disease models. The leaner mutation affects the Ca(v)2.1 voltage-gated calcium channel alpha(1A)-subunit gene, and homozygous mice show severe phenotypic alterations. Although several authors have described...

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PMID: 19389304
PMCID: PMC2703144

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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