Faster is not surer--a comparison of C57BL/6J and 129S2/Sv mouse strains in the watermaze.

Abstract excerpt

In recent years the use of genetic manipulations to investigate the molecular mechanisms underlying learning and memory has become a common approach. In a great many cases, the spatial learning ability of mutant mice has been assessed using the Morris watermaze task. The performance of these mice may, however, be strongly influenced by their genetic background and, therefore, the interpretation of their phenotype...

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