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Article

Spatial learning in transgenic mice expressing human presenilin 1 (PS1) transgenes.

Neurobiology of aging - 1 Jan 2000

Janus C, D'Amelio S, Amitay O, Chishti M A, Strome R, Fraser P, Carlson G A, Roder J C, St George-Hyslop P, Westaway D

Abstract excerpt

Dominant mutations in the Presenilin 1 gene are linked to an aggressive, early-onset form of familial Alzheimer's Disease (FAD). Spatial memory of transgenic (Tg) mice expressing either mutant (lines Tg(M146L)1, Tg(M146L)76, Tg(L286V)198) or wild type (line Tg(PS1wt)195) human PS1 transgenes was investigated in the Morris water maze (WM) test at 6 and 9 months of age. The results showed that the mutated Tg mice...

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PMID: 10924767
DOI: 10.1016/s0197-4580(00)00107-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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