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Article

Selective discrimination learning impairments in mice expressing the human Huntington's disease mutation.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Dec 1999

Lione L A, Carter R J, Hunt M J, Bates G P, Morton A J, Dunnett S B

Abstract excerpt

Cognitive decline is apparent in the early stages of Huntington's disease and progressively worsens throughout the course of the disease. Expression of the human Huntington's disease mutation in mice (R6/2 line) causes a progressive neurological phenotype with motor symptoms resembling those seen in Huntington's disease. Here we describe the cognitive performance of R6/2 mice using four different tests (Morris...

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Identifiers

PMID: 10575040
PMCID: PMC6782405

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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