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Article

Prodynorphin knockout mice demonstrate diminished age-associated impairment in spatial water maze performance.

Behavioural brain research - 20 Jun 2005

Nguyen Xuan V, Masse James, Kumar Ashok, Vijitruth Rattanavijit, Kulik Cynthia, Liu Mei, Choi Dong-Young, Foster Thomas C, Usynin Ivan, Bakalkin Georgy, Bing Guoying

Abstract excerpt

Dynorphins, endogenous kappa-opioid agonists widely expressed in the central nervous system, have been reported to increase following diverse pathophysiological processes, including excitotoxicity, chronic inflammation, and traumatic injury. These peptides have been implicated in cognitive impairment, especially that associated with aging. To determine whether absence of dynorphin confers any beneficial effect on...

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PMID: 15922052
DOI: 10.1016/j.bbr.2005.02.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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