Functional analysis of HBV genomes from patients with fulminant hepatitis.

doi:10.1002/hep.510280530

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Article

Functional analysis of HBV genomes from patients with fulminant hepatitis.

Hepatology (Baltimore, Md.) - 1 Nov 1998

Sterneck M, Kalinina T, Günther S, Fischer L, Santantonio T, Greten H, Will H

Abstract excerpt

Two previous case reports suggest that hepatitis B virus (HBV) core promoter variants with a high replication competence contribute to the pathogenesis of fulminant hepatitis B (FHB). We recently found in HBV genomes from patients with FHB an accumulation of mutations within the core promoter reg...

Topics

Base Sequence
DNA, Viral
Gene Expression
Hepatic Encephalopathy
Hepatitis B
Hepatitis B Core Antigens
Hepatitis B Surface Antigens
Hepatitis B e Antigens
Hepatitis B virus
Humans
Mutation
Virus Replication

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