Article
Whole genome analysis of hepatitis B virus from four cases of fulminant hepatitis: genetic variability and its potential role in disease pathogenicity.
Journal of viral hepatitis - 1 Jul 1996
Alexopoulou A, Karayiannis P, Hadziyannis S J, Hou J, Pickering J, Luo K, Thomas H C
Abstract excerpt
The precore stop-codon variant of hepatitis B virus (HBV) has been associated with fulminant hepatitis but is also found in patients with persistent infection and chronic hepatitis. We have examined the possibility that the severe outcome of infection in patients with fulminant disease may be a r...
Topics
- Amino Acid Sequence
- Codon, Terminator
- DNA, Viral
- Female
- Gene Expression Regulation, Viral
- Genetic Variation
- Genome, Viral
- Hepatitis B
- Hepatitis B e Antigens
- Hepatitis B virus
- Humans
- Male
- Molecular Sequence Data
- Mutagenesis, Insertional
- Polymerase Chain Reaction