Article
Deletion of the p53 Gene in a Patient with Aggressive Burn Scar Carcinoma
1 Jan 1997
Abstract excerpt
BACKGROUND: Aggressive squamous cell carcinoma (SCC) is known to occur in scars that develop after a burn injury, especially in the underdeveloped areas of the world where care is lacking. Because most SCC are associated with abnormalities in tumor suppressor genes, particularly p53, we postulated that similar mechanisms may underlie the development of burn-associated SCC. METHODS: We analyzed tissue DNA from a...
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