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Article

Analysis of p53 gene mutations in keloids using polymerase chain reaction-based single-strand conformational polymorphism and DNA sequencing.

Archives of dermatology - 1 Aug 1998

Saed G M, Ladin D, Olson J, Han X, Hou Z, Fivenson D

Abstract excerpt

BACKGROUND: Keloids are the result of a dysregulated wound healing process. They are characterized by the formation of excess scar tissue that proliferates beyond the boundaries of the original wound. Somatic mutations of p53 have been implicated as causal events in up to 50% of all human maligna...

Topics

Adult
Apoptosis
Arginine
Cell Death
Cell Division
Cells, Cultured
Codon
Cytosine
Exons
Fibroblasts
Frameshift Mutation
Genes, p53
Guanine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Keloid

Mouth Mucosa

Mutation

Polymerase Chain Reaction

Source

Identifiers

PMID: 9722726
DOI: 10.1001/archderm.134.8.963

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9722726-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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