Article
Frequent p53 gene mutations in soft tissue sarcomas arising in burn scar.
Japanese journal of cancer research : Gann - 1 Mar 1999
Nakanishi H, Tomita Y, Yoshikawa H, Sato N, Ochi T, Aozasa K
Abstract excerpt
Squamous cell carcinoma (SCC) is the commonest malignancy that arises in burn scars, which frequently contain p53 mutations. Soft tissue sarcoma (STS) also develops, though less frequently, in burn scars. p53 gene mutations were analyzed in paraffin-embedded specimens from 5 patients with STS (4 males and 1 female) that had arisen in a burn scar, by means of polymerase chain reaction-single strand conformation...
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