Article
Domain-specific gene disruption reveals critical regulation of neuregulin signaling by its cytoplasmic tail.
Proceedings of the National Academy of Sciences of the United States of America - 27 Oct 1998
Liu X, Hwang H, Cao L, Buckland M, Cunningham A, Chen J, Chien K R, Graham R M, Zhou M
Abstract excerpt
Neuregulins are a multi-isoform family of growth factors that activate members of the erbB family of receptor tyrosine kinases. The membrane-anchored isoforms contain the receptor-activating ligand in their extracellular domain, a single membrane-spanning region, and a long cytoplasmic tail. To evaluate the potential biological role of the intracellular domain of the membrane-anchored neuregulin isoforms, we used...
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