Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects

Abstract excerpt

The mammalian Nell1 gene encodes a protein kinase C-beta1 (PKC-beta1) binding protein that belongs to a new class of cell-signaling molecules controlling cell growth and differentiation. Over-expression of Nell1 in the developing cranial sutures in both human and mouse induces craniosynostosis, the premature fusion of the growing cranial bone fronts. Here, we report the generation, positional cloning and...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Bone and Dental Protein Studies
• Share to Connective tissue disorders research
• Share to Wnt/β-catenin signaling in development and cancer