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Article

Intramembranous valine linked to schizophrenia is required for neuregulin 1 regulation of the morphological development of cortical neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 7 Jul 2010

Chen Yachi, Hancock Melissa L, Role Lorna W, Talmage David A

Abstract excerpt

Neuregulin 1 (NRG1) signaling is critical to various aspects of neuronal development and function. Among different NRG1 isoforms, the type III isoforms of NRG1 are unique in their ability to signal via the intracellular domain after gamma-secretase-dependent intramembranous processing. However, the functional consequences of type III NRG1 signaling via its intracellular domain are mostly unknown. In this study,...

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Identifiers

PMID: 20610754
DOI: 10.1523/JNEUROSCI.0605-10.2010
PMCID: PMC2919805

Genes

NRG1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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