Article
Multiple essential functions of neuregulin in development.
Nature - 23 Nov 1995
Meyer D, Birchmeier C
Abstract excerpt
Neuregulin (also called NDF, heregulin, GGF and ARIA) is a member of the EGF family which induces growth and differentiation of epithelial, glial and muscle cells in culture. The biological effects of the factor are mediated by tyrosine kinase receptors. Neuregulin can bind directly to erbB3 and erbB4 and receptor heterodimerization allows neuregulin-dependent activation of erbB2 (refs 1, 2, 5). A targeted...
Topics
- Animals
- Cell Differentiation
- Cell Line
- Embryonic and Fetal Development
- ErbB Receptors
- Fetal Death
- Ganglia
- Glycoproteins
- Heart
- Mice
- Mice, Inbred C57BL
- Mutation