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Article

Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor.

Nature - 23 Nov 1995

Gassmann M, Casagranda F, Orioli D, Simon H, Lai C, Klein R, Lemke G

Abstract excerpt

Various in vitro studies have suggested that ErbB4 (HER4) is a receptor for the neuregulins, a family of closely related proteins implicated as regulators of neural and muscle development, and of the differentiation and oncogenic transformation of mammary epithelia. Here we demonstrate that ErbB4 is an essential in vivo regulator of both cardiac muscle differentiation and axon guidance in the central nervous...

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PMID: 7477376
DOI: 10.1038/378390a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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