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Article

Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor.

Nature - 23 Nov 1995

Gassmann M, Casagranda F, Orioli D, Simon H, Lai C, Klein R, Lemke G

Abstract excerpt

Various in vitro studies have suggested that ErbB4 (HER4) is a receptor for the neuregulins, a family of closely related proteins implicated as regulators of neural and muscle development, and of the differentiation and oncogenic transformation of mammary epithelia. Here we demonstrate that ErbB4...

Topics

Animals
Axons
Brain
Cell Line
Embryonic and Fetal Development
ErbB Receptors
Fetus
Ganglia
Gene Targeting
Glycoproteins
Heart
Humans
Immunoenzyme Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Inbred C57BL

Neuregulins

Phenotype

Receptor, ErbB-4

Source

Identifiers

PMID: 7477376
DOI: 10.1038/378390a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7477376-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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