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Article

The cytoplasmic domain of the large myelin-associated glycoprotein isoform is needed for proper CNS but not peripheral nervous system myelination.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Mar 1998

Fujita N, Kemper A, Dupree J, Nakayasu H, Bartsch U, Schachner M, Maeda N, Suzuki K, Popko B

Abstract excerpt

The myelin-associated glycoprotein (MAG) is a member of the immunoglobulin gene superfamily and is thought to play a critical role in the interaction of myelinating glial cells with the axon. Myelin from mutant mice incapable of expressing MAG displays various subtle abnormalities in the CNS and degenerates with age in the peripheral nervous system (PNS). Two distinct isoforms, large MAG (L-MAG) and small MAG...

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Identifiers

PMID: 9482783
PMCID: PMC6792935

Genes

MAG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The cytoplasmic domain of the large myelin-associated glycoprotein isoform is needed for proper CNS but not peripheral nervous system myelination.PMID 9482783Read ↗

Mice deficient for the myelin-associated glycoprotein show subtle abnormalities in myelin.Semantic proximity Read ↗

Multiple functions of the myelin-associated glycoprotein MAG (siglec-4a) in formation and maintenance of myelin.Semantic proximity Read ↗

Early onset of axonal degeneration in double (plp-/-mag-/-) and hypomyelinosis in triple (plp-/-mbp-/-mag-/-) mutant mice.Semantic proximity Read ↗

Severe hypomyelination of the murine CNS in the absence of myelin-associated glycoprotein and fyn tyrosine kinase.Semantic proximity Read ↗

Myelination and axonal regeneration in the central nervous system of mice deficient in the myelin-associated glycoprotein.Semantic proximity Read ↗

Myelin-associated glycoprotein and complementary axonal ligands, gangliosides, mediate axon stability in the CNS and PNS: neuropathology and behavioral deficits in single- and double-null mice.Semantic proximity Read ↗

Functional analysis in vivo of the double mutant mouse deficient in both proteolipid protein (PLP) and myelin basic protein (MBP) in the central nervous system.Semantic proximity Read ↗

Myelin-associated glycoprotein and myelin galactolipids stabilize developing axo-glial interactions.Semantic proximity Read ↗

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