Article
The cytoplasmic domain of the large myelin-associated glycoprotein isoform is needed for proper CNS but not peripheral nervous system myelination.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Mar 1998
Fujita N, Kemper A, Dupree J, Nakayasu H, Bartsch U, Schachner M, Maeda N, Suzuki K, Popko B
Abstract excerpt
The myelin-associated glycoprotein (MAG) is a member of the immunoglobulin gene superfamily and is thought to play a critical role in the interaction of myelinating glial cells with the axon. Myelin from mutant mice incapable of expressing MAG displays various subtle abnormalities in the CNS and...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- Central Nervous System
- Cytoplasm
- Gene Targeting
- Heterozygote
- Isomerism
- Mice
- Molecular Sequence Data
- Mutation
- Myelin Sheath
- Myelin-Associated Glycoprotein