Article
Generation and characterization of neuregulin-2-deficient mice.
Molecular and cellular biology - 1 Sept 2004
Britto Joanne M, Lukehurst Sherralee, Weller Renae, Fraser Chris, Qiu Yubin, Hertzog Paul, Busfield Samantha J
Abstract excerpt
The neuregulins (NRGs) are a family of four structurally related growth factors that are expressed in the developing and adult brain. NRG-1 is essential for normal heart formation and has been implicated in the development and maintenance of both neurons and glia. NRG-2 was identified on the basis of its homology to NRG-1 and, like NRG-1, is expressed predominantly by neurons in the central nervous system. We...
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