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Remarkably similar antigen receptors among a subset of patients with chronic lymphocytic leukemia

1 Apr 2004

Abstract excerpt

Studies of B cell antigen receptors (BCRs) expressed by leukemic lymphocytes from patients with B cell chronic lymphocytic leukemia (B-CLL) suggest that B lymphocytes with some level of BCR structural restriction become transformed. While analyzing rearranged V(H)DJ(H) and V(L)J(L) genes of 25 non-IgM-producing B-CLL cases, we found five IgG(+) cases that display strikingly similar BCRs (use of the same H- and...

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PMID: 15057307
DOI: 10.1172/jci19399

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