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Article

B-cell receptor signaling in chronic lymphocytic leukemia

5 Aug 2011

Abstract excerpt

The B-cell receptor (BCR) is a key survival molecule for normal B cells and for most B-cell malignancies. Recombinatorial and mutational patterns in the clonal immunoglobulin (Ig) of chronic lymphocytic leukemia (CLL) have revealed 2 major IgMD-expressing subsets and an isotype-switched variant, each developing from distinct B-cell populations. Tracking of conserved stereotypic features of Ig variable regions...

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PMID: 21816833
DOI: 10.1182/blood-2011-06-338855

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