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Article

The role of B cell receptor stimulation in CLL pathogenesis.

Current pharmaceutical design - 1 Jan 2012

Kil Laurens P, Yuvaraj Saravanan, Langerak Anton W, Hendriks Rudi W

Abstract excerpt

Chronic lymphocytic leukemia (CLL) is the most frequent leukemia in adults in the Western world and is characterized by the accumulation of monoclonal CD5(+) mature B cells in the blood. The disease has a highly variable clinical course. CLL is subdivided into two disease subtypes, whereby leukemias with hypermutated immunoglobulin heavy chain variable (IGHV) genes have a more favorable prognosis than those with...

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Share to Chromosome Aberrations
Share to BCR gene
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Receptors, Antigen, B-Cell

Source

Identifiers

PMID: 22591389
DOI: 10.2174/138161212801227041

Genes

BCR
ZAP70

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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