Article
Impact of CYP2E1 genotype in renal cell and urothelial cancer patients.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie - 1 Sept 1998
Farker K, Lehmann M H, Oelschlägel B, Haerting J, Hoffmann A, Janitzky V, Schubert J
Abstract excerpt
Genetic polymorphisms of enzymes involved in carcinogen metabolism have been found to influence susceptibility to cancer. Ethanol-inducible CYP2E1 is an enzyme of major toxicological interest because it metabolizes several drugs, precarcinogens and solvents to reactive metabolites. In the present...
Topics
- Carcinoma, Renal Cell
- Carcinoma, Transitional Cell
- Case-Control Studies
- Cytochrome P-450 CYP2E1
- DNA Primers
- DNA, Neoplasm
- Female
- Genotype
- Humans
- Kidney Neoplasms
- Male
- Odds Ratio
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Polymorphism, Restriction Fragment Length
- Risk Factors
- Urinary Bladder Neoplasms