Article
Analysis of point mutation in exon 2 of CYP2E1 gene in renal cell/urothelial cancer patients in comparison with control population.
International journal of clinical pharmacology and therapeutics - 1 Jan 2000
Farker K, Lehmann M H, Kästner R, Weber J, Janitzky V, Schubert J, Hoffmann A
Abstract excerpt
OBJECTIVE: Genetic polymorphisms of human cytochrome P450s have been implicated to be of importance for susceptibility to different cancers. Recently, a point mutation was found in the exon 2 of the CYP2E1 gene (CYP2E1*2) [Hu et al. 1997]. In order to evaluate a possible link between the point mutation in exon 2 of the CYP2E1 gene and the susceptibility to renal cell/urothelial cancer, we developed a screening...
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