Article
Glutathione transferase activities in renal carcinomas and adjacent normal renal tissues: factors influencing renal carcinogenesis induced by xenobiotics.
Archives of toxicology - 1 Jan 2001
Delbanco E H, Bolt H M, Huber W W, Beken S, Geller F, Philippou S, Brands F H, Brüning T, Thier R
Abstract excerpt
In general, the biological activation of nephrocarcinogenic chlorinated hydrocarbons proceeds via conjugation with glutathione. It has mostly been assumed that the main site of initial conjugation is the liver, followed by a mandatory transfer of intermediates to the kidney. It was therefore of interest to study the enzyme activities of subgroups of glutathione transferases (GSTs) in renal cancers and the...
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