Article
CYP2E1 genotyping in renal cell/urothelial cancer patients in comparison with control populations.
International journal of clinical pharmacology and therapeutics - 1 Sept 1998
Farker K, Lehmann M H, Kästner R, Hoffmann A, Janitzky V, Schubert J, Matz U, Hofmann W
Abstract excerpt
OBJECTIVE: Genetic polymorphisms in enzymes involved in carcinogen metabolism have been found to influence susceptibility to cancer. Ethanol-inducible CYP2E1 is an enzyme of major toxicological interest because it metabolizes several drugs, precarcinogens, and solvents to reactive metabolites. In the present investigation, we studied the cytochrome P450 2E1 genetic polymorphism in renal cell/urothelial cancer...
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