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Article

Alterations of per RNA in noncoding regions affect periodicity of circadian behavioral rhythms.

Journal of biological rhythms - 1 Oct 1998

Chen Y, Hunter-Ensor M, Schotland P, Sehgal A

Abstract excerpt

Circadian rhythms in Drosophila depend on a molecular feedback loop that includes products of the period (per) and timeless (tim) genes. RNA and protein products of both genes cycle with a circadian period and the proteins feedback to inhibit expression of their own mRNAs. While cyclic expression of PER protein appears to be necessary for rhythmic behavior, the function of per RNA cycling is somewhat...

Topics

Animals
Behavior, Animal
Circadian Rhythm
Drosophila Proteins
Gene Deletion
Gene Expression
Nuclear Proteins
Period Circadian Proteins
Periodicity
Phenotype
Polyribosomes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA

Transgenes

Tubulin

Untranslated Regions

Source

Identifiers

PMID: 9783228
DOI: 10.1177/074873098129000192

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-9783228-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Alterations of per RNA in noncoding regions affect periodicity of circadian behavioral rhythms.PMID 9783228Read ↗

Mapping of elements involved in regulating normal temporal period and timeless RNA expression patterns in Drosophila melanogaster.Semantic proximity Read ↗

Altered entrainment and feedback loop function effected by a mutant period protein.Semantic proximity Read ↗

Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels.Semantic proximity Read ↗

Rhythmic expression of timeless: a basis for promoting circadian cycles in period gene autoregulation.Semantic proximity Read ↗

Role of molecular oscillations in generating behavioral rhythms in Drosophila.Semantic proximity Read ↗

Suppression of PERIOD protein abundance and circadian cycling by the Drosophila clock mutation timeless.Semantic proximity Read ↗

Regulation of the cycling of timeless (tim) RNA.Semantic proximity Read ↗

The strength and periodicity of D. melanogaster circadian rhythms are differentially affected by alterations in period gene expression.Semantic proximity Read ↗

Changes in abundance or structure of the per gene product can alter periodicity of the Drosophila clock.Semantic proximity Read ↗

Influence of the period-dependent circadian clock on diurnal, circadian, and aperiodic gene expression in Drosophila melanogaster.Semantic proximity Read ↗

Cooperative interaction between phosphorylation sites on PERIOD maintains circadian period in Drosophila.Semantic proximity Read ↗

The novel gene twenty-four defines a critical translational step in the Drosophila clock.Semantic proximity Read ↗

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