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Article

Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels.

Nature - 8 Feb 1990

Hardin P E, Hall J C, Rosbash M

Abstract excerpt

Mutations in the period (per) gene of Drosophila melanogaster affect both circadian and ultradian rhythms. Levels of per gene product undergo circadian oscillation, and it is now shown that there is an underlying oscillation in the level of per RNA. The observations indicate that the cycling of per-encoded protein could result from per RNA cycling, and that there is a feedback loop through which the activity of...

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Identifiers

PMID: 2105471
DOI: 10.1038/343536a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels.PMID 2105471Read ↗

Alterations of per RNA in noncoding regions affect periodicity of circadian behavioral rhythms.Semantic proximity Read ↗

Altered entrainment and feedback loop function effected by a mutant period protein.Semantic proximity Read ↗

Influence of the period-dependent circadian clock on diurnal, circadian, and aperiodic gene expression in Drosophila melanogaster.Semantic proximity Read ↗

Temporal phosphorylation of the Drosophila period protein.Semantic proximity Read ↗

Mapping of elements involved in regulating normal temporal period and timeless RNA expression patterns in Drosophila melanogaster.Semantic proximity Read ↗

Interlocked feedback loops within the Drosophila circadian oscillator.Semantic proximity Read ↗

Changes in abundance or structure of the per gene product can alter periodicity of the Drosophila clock.Semantic proximity Read ↗

Circadian fluctuations of period protein immunoreactivity in the CNS and the visual system of Drosophila.Semantic proximity Read ↗

The Drosophila double-timeS mutation delays the nuclear accumulation of period protein and affects the feedback regulation of period mRNA.Semantic proximity Read ↗

New short period mutations of the Drosophila clock gene per.Semantic proximity Read ↗

The strength and periodicity of D. melanogaster circadian rhythms are differentially affected by alterations in period gene expression.Semantic proximity Read ↗

Suppression of PERIOD protein abundance and circadian cycling by the Drosophila clock mutation timeless.Semantic proximity Read ↗

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