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Article

Regulation of the cycling of timeless (tim) RNA.

Journal of neurobiology - 5 Jun 2001

Wang G K, Ousley A, Darlington T K, Chen D, Chen Y, Fu W, Hickman L J, Kay S A, Sehgal A

Abstract excerpt

Circadian rhythms in Drosophila depend upon expression of the timeless (tim) and period (per) genes, which encode interacting components of the endogenous clock. These two clock genes show a robust circadian oscillation in transcription rate as well as RNA and protein levels. Transcriptional activation of both genes requires the basic helix-loop-helix (bHLH) PAS transcription factors dCLOCK (dCLK) and CYCLE...

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Identifiers

PMID: 11333398
DOI: 10.1002/neu.1024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of the cycling of timeless (tim) RNA.PMID 11333398Read ↗

Rhythmic expression of timeless: a basis for promoting circadian cycles in period gene autoregulation.Semantic proximity Read ↗

Clock-gated photic stimulation of timeless expression at cold temperatures and seasonal adaptation in Drosophila.Semantic proximity Read ↗

A TIMELESS-independent function for PERIOD proteins in the Drosophila clock.Semantic proximity Read ↗

dCLOCK is present in limiting amounts and likely mediates daily interactions between the dCLOCK-CYC transcription factor and the PER-TIM complex.Semantic proximity Read ↗

Suppression of PERIOD protein abundance and circadian cycling by the Drosophila clock mutation timeless.Semantic proximity Read ↗

CYCLE is a second bHLH-PAS clock protein essential for circadian rhythmicity and transcription of Drosophila period and timeless.Semantic proximity Read ↗

Functional molecular analysis of a circadian clock gene timeless promoter from the Drosophilid fly Chymomyza costata.Semantic proximity Read ↗

Interlocked feedback loops within the Drosophila circadian oscillator.Semantic proximity Read ↗

Molecular control of circadian behavioral rhythms.Semantic proximity Read ↗

A PER/TIM/DBT interval timer for Drosophila's circadian clock.Semantic proximity Read ↗

Clockwork orange encodes a transcriptional repressor important for circadian-clock amplitude in Drosophila.Semantic proximity Read ↗

TIMELESS is an important mediator of CK2 effects on circadian clock function in vivo.Semantic proximity Read ↗

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