Article
Rhythmic expression of timeless: a basis for promoting circadian cycles in period gene autoregulation.
Science (New York, N.Y.) - 3 Nov 1995
Sehgal A, Rothenfluh-Hilfiker A, Hunter-Ensor M, Chen Y, Myers M P, Young M W
Abstract excerpt
The clock gene timeless (tim) is required for circadian rhythmicity in Drosophila. The accumulation of tim RNA followed a circadian rhythm, and the phase and period of the tim RNA rhythm were indistinguishable from those that have been reported for per. The tim RNA oscillations were found to be dependent on the presence of PER and TIM proteins, which demonstrates feedback control of tim by a mechanism previously...
Topics
- Animals
- Biological Clocks
- Circadian Rhythm
- Darkness
- Drosophila Proteins
- Drosophila melanogaster
- Gene Expression Regulation
- Genes, Insect
- Mutation
- Nuclear Proteins
- Period Circadian Proteins