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Article

Low dose poly I:C prevents diabetes in the diabetes prone BB rat.

Journal of autoimmunity - 1 Aug 1998

Sobel D O, Goyal D, Ahvazi B, Yoon J W, Chung Y H, Bagg A, Harlan D M

Abstract excerpt

Poly I:C, an inducer of IFN-alpha and other cytokines, has been used to study the development of diabetes in both the BioBreeding (BB) diabetes prone rat and non-obese diabetic (NOD) mouse animal models of insulin-dependent diabetes mellitus (IDDM). Surprisingly, poly I:C accelerates the disease in the BB rat while inhibiting it in the NOD mouse. Since cytokines can have dose related opposing effects on immune...

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Identifiers

PMID: 9776712
DOI: 10.1006/jaut.1998.0203

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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