Low dose poly I:C prevents diabetes in the diabetes prone BB rat.

doi:10.1006/jaut.1998.0203

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Low dose poly I:C prevents diabetes in the diabetes prone BB rat.

Journal of autoimmunity - 1 Aug 1998

Sobel D O, Goyal D, Ahvazi B, Yoon J W, Chung Y H, Bagg A, Harlan D M

Abstract excerpt

Poly I:C, an inducer of IFN-alpha and other cytokines, has been used to study the development of diabetes in both the BioBreeding (BB) diabetes prone rat and non-obese diabetic (NOD) mouse animal models of insulin-dependent diabetes mellitus (IDDM). Surprisingly, poly I:C accelerates the disease in the BB rat while inhibiting it in the NOD mouse. Since cytokines can have dose related opposing effects on immune...

Topics

Animals
Body Weight
Concanavalin A
Cytokines
Diabetes Mellitus, Type 1
Dose-Response Relationship, Drug
Flow Cytometry
Gene Expression
Histocompatibility Antigens Class I
Interferon Inducers
Islets of Langerhans
Leukocyte Count
Leukocytes, Mononuclear
Lymphocyte Activation

Source

Open in PubMed

Identifiers

PMID: 9776712
DOI: 10.1006/jaut.1998.0203

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Phenotype

Poly I-C

Rats