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Article

T cell reconstitution of BB/W rats after the initiation of insulitis precipitates the onset of diabetes.

Journal of immunology (Baltimore, Md. : 1950) - 1 May 1999

Ramanathan S, Poussier P

Abstract excerpt

One of the diabetes susceptibility genes of the BB/W (Biobreeding/Worcester) rat maps to the lyp locus on chromosome 4. The BB/W lyp allele is responsible for a severe peripheral T lymphopenia. Correction of this lymphopenia by transfer of normal, histocompatible T cells prevents diabetes, providing T cell reconstitution is initiated before insulitis. We have analyzed this time-dependent regulation of the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10227984

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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T cell reconstitution of BB/W rats after the initiation of insulitis precipitates the onset of diabetes.PMID 10227984Read ↗

BB rat <i>lyp</i> mutation and Type 1 diabetesSemantic proximity Read ↗

Non-major histocompatibility complex-linked diabetes susceptibility loci on chromosomes 4 and 13 in a backcross of the DP-BB/Wor rat to the WF rat.Semantic proximity Read ↗

Rel B is an early marker of autoimmune islet inflammation in the biobreeding (BB) rat.Semantic proximity Read ↗

Impaired post-thymic development of regulatory CD4+25+ T cells contributes to diabetes pathogenesis in BB rats.Semantic proximity Read ↗

Diabetes-prone and diabetes-resistant BB rats share a common major diabetes susceptibility locus, iddm4: additional evidence for a "universal autoimmunity locus" on rat chromosome 4.Semantic proximity Read ↗

Deficiencies in gut NK cell number and function precede diabetes onset in BB rats.Semantic proximity Read ↗

Type 1 diabetes in BioBreeding rats is critically linked to an imbalance between Th17 and regulatory T cells and an altered TCR repertoire.Semantic proximity Read ↗

CD8+ T-cells are required for adoptive transfer of the BB rat diabetic syndrome.Semantic proximity Read ↗

Excessive production of nitric oxide by macrophages from DP-BB rats is secondary to the T-lymphopenic state of these animals.Semantic proximity Read ↗

Defects in differentiation of bone-marrow derived dendritic cells of the BB rat are partly associated with IDDM2 (the lyp gene) and partly associated with other genes in the BB rat background.Semantic proximity Read ↗

Inclusion of peripancreatic lymph node cells prevents recurrent autoimmune destruction of islet transplants: evidence of donor chimerism.Semantic proximity Read ↗

Iddm30 controls pancreatic expression of Ccl11 (Eotaxin) and the Th1/Th2 balance within the insulitic lesions.Semantic proximity Read ↗

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