Article
T cell reconstitution of BB/W rats after the initiation of insulitis precipitates the onset of diabetes.
Journal of immunology (Baltimore, Md. : 1950) - 1 May 1999
Ramanathan S, Poussier P
Abstract excerpt
One of the diabetes susceptibility genes of the BB/W (Biobreeding/Worcester) rat maps to the lyp locus on chromosome 4. The BB/W lyp allele is responsible for a severe peripheral T lymphopenia. Correction of this lymphopenia by transfer of normal, histocompatible T cells prevents diabetes, providing T cell reconstitution is initiated before insulitis. We have analyzed this time-dependent regulation of the...
Topics
- ADP Ribose Transferases
- Adoptive Transfer
- Animals
- Animals, Congenic
- Antigens, Differentiation, T-Lymphocyte
- Diabetes Mellitus, Type 1
- Genetic Predisposition to Disease
- Injections, Intravenous
- Islets of Langerhans
- Lymphocyte Activation
- Lymphocyte Count
- Lymphocyte Transfusion
- Male
- Membrane Glycoproteins
- Rats
- Rats, Inbred BB
- Rats, Inbred WF
- T-Lymphocyte Subsets