Article
Gamma interferon prevents diabetes in the BB rat.
Clinical and diagnostic laboratory immunology - 1 Nov 1997
Sobel D O, Newsome J
Abstract excerpt
The BB rat model of human insulin-dependent diabetes mellitus (IDDM) spontaneously develops diabetes through an autoimmune process. Gamma interferon (IFN-gamma) is thought to play an important pathogenic role. This study examined if IFN-gamma administration can, paradoxically, prevent diabetes in...
Topics
- Age Factors
- Animals
- Diabetes Mellitus, Type 1
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Drug Administration Schedule
- Female
- Glucose Tolerance Test
- Humans
- Interferon-gamma
- Male
- Mice
- Pancreas
- Phenotype
- Rats
- Rats, Inbred BB
- Recombinant Proteins