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Article

Human insulin B chain but not A chain decreases the rate of diabetes in BB rats.

Diabetes research and clinical practice - 1 Nov 1999

Song H Y, Abad M M, Mahoney C P, McEvoy R C

Abstract excerpt

The autoimmune response seen in insulin-dependent diabetes mellitus (IDDM) includes a humoral immune response against human insulin. Early insulin treatment has been used to prevent IDDM in the rodent models of IDDM, and a prevention trial is underway in humans. The metabolic effects of insulin may not be involved in this prevention since, in NOD mice, the use of metabolically inert human insulin B chain was...

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Identifiers

PMID: 10724088
DOI: 10.1016/s0168-8227(99)00080-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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