Article
Paradoxical antidiabetogenic effect of gamma-interferon in DP-BB rats.
Diabetes - 1 Jan 1998
Nicoletti F, Zaccone P, Di Marco R, Magro G, Grasso S, Stivala F, Calori G, Mughini L, Meroni P L, Garotta G
Abstract excerpt
Previous studies have shown that anti-gamma-interferon (IFN-gamma) antibody reduces the frequency of autoimmune IDDM in the DP-BB rat. We tested the effects of systemically administered recombinant rat IFN-gamma in both DP-BB and DR-BB rats. Unexpectedly, IFN-gamma markedly reduced the incidence...
Topics
- Aging
- Animals
- Concanavalin A
- Diabetes Mellitus, Experimental
- Diabetes Mellitus, Type 1
- Dose-Response Relationship, Drug
- Female
- Histocompatibility Antigens Class II
- Hypoglycemic Agents
- Immunosuppressive Agents
- Incidence
- Injections, Intraperitoneal
- Interferon-gamma
- Macrophages, Peritoneal
- Male
- Phenotype
- Random Allocation
- Rats