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Article

Characterization of novel parent-specific epigenetic modifications upstream of the imprinted mouse H19 gene.

Molecular and cellular biology - 1 Nov 1998

Szabó P E, Pfeifer G P, Mann J R

Abstract excerpt

Genomic imprinting results in parent-specific monoallelic expression of a small number of genes in mammals. The identity of imprints is unknown, but much evidence points to a role for DNA methylation. The maternal alleles of the imprinted H19 gene are active and hypomethylated; the paternal alleles are inactive and hypermethylated. Roles for other epigenetic modifications are suggested by allele-specific...

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Identifiers

PMID: 9774690
DOI: 10.1128/MCB.18.11.6767
PMCID: PMC109260

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Characterization of novel parent-specific epigenetic modifications upstream of the imprinted mouse H19 gene.PMID 9774690Read ↗

A 5' 2-kilobase-pair region of the imprinted mouse H19 gene exhibits exclusive paternal methylation throughout development.Semantic proximity Read ↗

Parental allele-specific chromatin configuration in a boundary-imprinting-control element upstream of the mouse H19 gene.Semantic proximity Read ↗

Dynamic readjustment of parental methylation patterns of the 5'-flank of the mouse H19 gene during in vitro organogenesis.Semantic proximity Read ↗

A paternal-specific methylation imprint marks the alleles of the mouse H19 gene.Semantic proximity Read ↗

Mouse/human sequence divergence in a region with a paternal-specific methylation imprint at the human H19 locus.Semantic proximity Read ↗

Epigenetic mechanisms underlying the imprinting of the mouse H19 gene.Semantic proximity Read ↗

Imprinted expression and methylation of the mouse H19 gene are conserved in extraembryonic lineages.Semantic proximity Read ↗

Developmental control of allelic methylation in the imprinted mouse Igf2 and H19 genes.Semantic proximity Read ↗

The paternal allele of the H19 gene is progressively silenced during early mouse development: the acetylation status of histones may be involved in the generation of variegated expression patterns.Semantic proximity Read ↗

Acquisition of the H19 methylation imprint occurs differentially on the parental alleles during spermatogenesis.Semantic proximity Read ↗

The H19 methylation imprint is erased and re-established differentially on the parental alleles during male germ cell development.Semantic proximity Read ↗

Deletion of a silencer element disruptsH19imprinting independently of a DNA methylation epigenetic switchSemantic proximity Read ↗

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