Characterization of novel parent-specific epigenetic modifications upstream of the imprinted mouse H19 gene.

doi:10.1128/MCB.18.11.6767

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Article

Characterization of novel parent-specific epigenetic modifications upstream of the imprinted mouse H19 gene.

Molecular and cellular biology - 1 Nov 1998

Szabó P E, Pfeifer G P, Mann J R

Abstract excerpt

Genomic imprinting results in parent-specific monoallelic expression of a small number of genes in mammals. The identity of imprints is unknown, but much evidence points to a role for DNA methylation. The maternal alleles of the imprinted H19 gene are active and hypomethylated; the paternal allel...

Topics

Alleles
Animals
Base Sequence
Chromatin
DNA Footprinting
DNA Methylation
DNA-Binding Proteins
Deoxyribonuclease I
Gene Expression Regulation
Genomic Imprinting
Mice
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Muscle Proteins

Podophyllin

Podophyllotoxin

Promoter Regions, Genetic

RNA, Long Noncoding

RNA, Untranslated

Source

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Identifiers

PMID: 9774690
DOI: 10.1128/MCB.18.11.6767
PMCID: PMC109260

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9774690-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Characterization of novel parent-specific epigenetic modifications upstream of the imprinted mouse H19 gene.PMID 9774690Read ↗

A 5' 2-kilobase-pair region of the imprinted mouse H19 gene exhibits exclusive paternal methylation throughout development.Semantic proximity Read ↗

Parental allele-specific chromatin configuration in a boundary-imprinting-control element upstream of the mouse H19 gene.Semantic proximity Read ↗

Dynamic readjustment of parental methylation patterns of the 5'-flank of the mouse H19 gene during in vitro organogenesis.Semantic proximity Read ↗

A paternal-specific methylation imprint marks the alleles of the mouse H19 gene.Semantic proximity Read ↗

Mouse/human sequence divergence in a region with a paternal-specific methylation imprint at the human H19 locus.Semantic proximity Read ↗

Epigenetic mechanisms underlying the imprinting of the mouse H19 gene.Semantic proximity Read ↗

Imprinted expression and methylation of the mouse H19 gene are conserved in extraembryonic lineages.Semantic proximity Read ↗

Developmental control of allelic methylation in the imprinted mouse Igf2 and H19 genes.Semantic proximity Read ↗

The paternal allele of the H19 gene is progressively silenced during early mouse development: the acetylation status of histones may be involved in the generation of variegated expression patterns.Semantic proximity Read ↗

Acquisition of the H19 methylation imprint occurs differentially on the parental alleles during spermatogenesis.Semantic proximity Read ↗

The H19 methylation imprint is erased and re-established differentially on the parental alleles during male germ cell development.Semantic proximity Read ↗

Deletion of a silencer element disruptsH19imprinting independently of a DNA methylation epigenetic switchSemantic proximity Read ↗

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