Article
The paternal allele of the H19 gene is progressively silenced during early mouse development: the acetylation status of histones may be involved in the generation of variegated expression patterns.
Development (Cambridge, England) - 1 Jan 1998
Svensson K, Mattsson R, James T C, Wentzel P, Pilartz M, MacLaughlin J, Miller S J, Olsson T, Eriksson U J, Ohlsson R
Abstract excerpt
Transcriptional silencing can reflect heritable, epigenetic inactivation of genes, either singly or in groups, during the life-time of an organism. This phenomenon is exemplified by parent-of-origin-specific inactivation events (genomic imprinting) for a subset of mammalian autosomal genes, such...
Topics
- Acetylation
- Alleles
- Animals
- Embryonic and Fetal Development
- Enzyme Inhibitors
- Gene Expression Regulation, Developmental
- Genomic Imprinting
- Genotype
- Histone Deacetylase Inhibitors
- Histone Deacetylases
- Histones
- Hydroxamic Acids
- In Situ Hybridization