Article
Phosphoinositide 3-kinase regulation of T cell receptor-mediated interleukin-2 gene expression in normal T cells.
The Journal of biological chemistry - 23 Oct 1998
Eder A M, Dominguez L, Franke T F, Ashwell J D
Abstract excerpt
Phosphoinositide (PI) 3-kinase has been implicated in T cell receptor (TCR) signaling, either as a positive or a negative regulatory molecule. Here, we show that for normal mouse lymph node T cells, PI 3-kinase activity is required for interleukin-2 (IL-2) production following TCR-mediated activa...
Topics
- Androstadienes
- Animals
- Chromones
- Enzyme Activation
- Female
- Interleukin-2
- Lymph Nodes
- Lymphocyte Activation
- MAP Kinase Kinase 1
- Male
- Mice
- Mice, Inbred C57BL
- Mitogen-Activated Protein Kinase 1
- Mitogen-Activated Protein Kinase Kinases
- Mitogen-Activated Protein Kinases
- Morpholines
- Mutation
- Phosphatidylinositol 3-Kinases